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LOC126862016 CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:87896478-87897677 [ Homo sapiens (human) ]

Gene ID: 126862016, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862016
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:87896478-87897677
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (87430134..87431333)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (81650894..81652093)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1148 Neighboring gene NANOG hESC enhancer GRCh37_chr14:87475731-87476275 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:87483369-87484231 Neighboring gene NANOG hESC enhancer GRCh37_chr14:87486385-87486995 Neighboring gene uncharacterized LOC105370608 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:87599502-87600701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:87621174-87621674 Neighboring gene NANOG hESC enhancer GRCh37_chr14:87623147-87623726 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:87636358-87637056 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:87652958-87653633 Neighboring gene NANOG hESC enhancer GRCh37_chr14:87701004-87701521 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:87706805-87707606 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:87726633-87727391 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:87809385-87810584 Neighboring gene long intergenic non-protein coding RNA 2296 Neighboring gene long intergenic non-protein coding RNA 2330 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88228569-88229110 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:88263144-88263835 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:88296681-88297225 Neighboring gene Sharpr-MPRA regulatory region 1922 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38563 Neighboring gene shieldin complex subunit 2 pseudogene 2 Neighboring gene galactosylceramidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086514.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    87430134..87431333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    81650894..81652093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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