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LOC126861967 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:65822645-65823844 [ Homo sapiens (human) ]

Gene ID: 126861967, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861967
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:65822645-65823844
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126861967 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (65355927..65357126)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (59560743..59561942)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65748624-65749192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8554 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8555 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8558 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:65795645-65796416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65797276-65797886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8559 Neighboring gene microRNA 4708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8562 Neighboring gene fucosyltransferase 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5851 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65880189-65880753 Neighboring gene MPRA-validated peak2170 silencer Neighboring gene MPRA-validated peak2171 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8564 Neighboring gene FUT8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8565 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_35208 Neighboring gene ribosomal protein L21 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 8561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086465.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    65355927..65357126
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    59560743..59561942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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