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LOC126861701 BRD4-independent group 4 enhancer GRCh37_chr12:133433141-133434340 [ Homo sapiens (human) ]

Gene ID: 126861701, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861701
Gene description
BRD4-independent group 4 enhancer GRCh37_chr12:133433141-133434340
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861701 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132856555..132857754)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132907354..132908520)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene golgin A3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5130 Neighboring gene ribosomal protein S11 pseudogene 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:133412143-133413342 Neighboring gene RNA, U6 small nuclear 327, pseudogene Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133428785-133429286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133429287-133429786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133449077-133449774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133449775-133450470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133450471-133451166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133451167-133451862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7393 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133464984-133465786 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:133465787-133466587 Neighboring gene CHFR divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr12:133474434-133475172 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086199.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132856555..132857754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132907354..132908520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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