U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126861655 BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211 [ Homo sapiens (human) ]

Gene ID: 126861655, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126861655
Gene description
BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119679207..119680406)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119666491..119667690)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:119807339-119808538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7114 Neighboring gene coiled-coil domain containing 60 Neighboring gene uncharacterized LOC105370027 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119828163-119828664 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119861020-119861540 Neighboring gene MPRA-validated peak2000 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:119924434-119924986 Neighboring gene MPRA-validated peak2001 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120031567-120032140 Neighboring gene transmembrane protein 233 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120106633-120107268 Neighboring gene uncharacterized LOC124903033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115709-120116208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115207-120115708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120125555-120126425 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120185956-120187155 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120192166-120192349 Neighboring gene microRNA 1178 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120197803-120197989 Neighboring gene citron rho-interacting serine/threonine kinase Neighboring gene NANOG hESC enhancer GRCh37_chr12:120213039-120213640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120242131-120242682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120306702-120307901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4931 Neighboring gene uncharacterized LOC112268087 Neighboring gene ribosomal protein L35a pseudogene 30

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086153.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    119679207..119680406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    119666491..119667690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases