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LOC126861645 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:115778674-115779873 [ Homo sapiens (human) ]

Gene ID: 126861645, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861645
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:115778674-115779873
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (115340869..115342068)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (115319241..115320440)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:115450672-115451172 Neighboring gene MPRA-validated peak1978 silencer Neighboring gene uncharacterized LOC124903081 Neighboring gene NANOG hESC enhancer GRCh37_chr12:115596667-115597168 Neighboring gene NANOG hESC enhancer GRCh37_chr12:115636884-115637385 Neighboring gene MPRA-validated peak1981 silencer Neighboring gene uncharacterized LOC124903082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:115722922-115723464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:115723465-115724005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:115813067-115813567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7082 Neighboring gene uncharacterized LOC105370003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7083 Neighboring gene Sharpr-MPRA regulatory region 1364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4898 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:115912063-115913262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7085 Neighboring gene Sharpr-MPRA regulatory region 2221 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:115945721-115946321 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:115949721-115950428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7087 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24966 Neighboring gene uncharacterized LOC105370002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:116061414-116061930 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 9136 Neighboring gene RNA, 7SL, cytoplasmic 865, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086143.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    115340869..115342068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    115319241..115320440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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