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LOC126861359 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:118782402-118783601 [ Homo sapiens (human) ]

Gene ID: 126861359, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861359
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:118782402-118783601
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. The major subregion had activity in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were also shown to be active enhancers by ChIP-STARR-seq in human embryonic stem cells. [provided by RefSeq, Nov 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118911693..118913051)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118931932..118933290)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118758848-118759465 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118766473-118767231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118768851-118769358 Neighboring gene BCL9 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118779970-118780511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118781595-118782134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118784843-118785382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118785383-118785924 Neighboring gene microRNA 4492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118787549-118788090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118788631-118789172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118792419-118792959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118794043-118794583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118794584-118795123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118795793-118796294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118798447-118798948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5613 Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118810343-118811124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118811125-118811904 Neighboring gene uroplakin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118782677-118783218
  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118783219-118783760

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085858.2 

    Range
    101..1459
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118911693..118913051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118931932..118933290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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