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LOC126861351 MED14-independent group 3 enhancer GRCh37_chr11:115974681-115975880 [ Homo sapiens (human) ]

Gene ID: 126861351, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861351
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:115974681-115975880
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (116103964..116105163)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (116117095..116118295)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115822621-115823122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115823123-115823622 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:115837993-115838563 Neighboring gene ribosomal protein L15 pseudogene 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115850711-115851212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115851213-115851712 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:115856308-115857507 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5551 Neighboring gene uncharacterized LOC105369513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115923025-115923556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:115923557-115924088 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115930586-115931146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5553 Neighboring gene uncharacterized LOC107984393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116001721-116002220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116038044-116038544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116038545-116039045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116047950-116048450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116048451-116048951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116051365-116051866 Neighboring gene Sharpr-MPRA regulatory region 5427 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:116105565-116106066 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:116106067-116106566 Neighboring gene Sharpr-MPRA regulatory region 931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116136339-116136840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116136841-116137340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:116146332-116147282 Neighboring gene uncharacterized LOC107987166 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085850.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    116103964..116105163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    116117095..116118295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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