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LOC126861312 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:100620727-100621926 [ Homo sapiens (human) ]

Gene ID: 126861312, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861312
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:100620727-100621926
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861312 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (100749996..100751195)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (100759161..100760359)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:100549285-100549786 Neighboring gene ARHGAP42 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:100569215-100569715 Neighboring gene Rho GTPase activating protein 42 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:100596358-100597237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5429 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:100618800-100619666 Neighboring gene Sharpr-MPRA regulatory region 13184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:100698323-100699048 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:100699049-100699774 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:100699775-100700498 Neighboring gene Sharpr-MPRA regulatory region 13718 Neighboring gene RN7SK pseudogene 115 Neighboring gene uncharacterized LOC105369457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085811.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    100749996..100751195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    100759161..100760359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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