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LOC126861201 MED14-independent group 3 enhancer GRCh37_chr11:44218806-44220005 [ Homo sapiens (human) ]

Gene ID: 126861201, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861201
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:44218806-44220005
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (44197256..44198455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44352610..44353809)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43964814-43965643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43965644-43966472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43968482-43968982 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:43977126-43977352 Neighboring gene chromosome 11 open reading frame 96 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44003904-44004404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44004405-44004905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44026425-44027286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44028815-44029314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44035825-44036324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4652 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Neighboring gene exostosin glycosyltransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44199715-44200215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44283363-44283862 Neighboring gene VISTA enhancer hs2090 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:44299108-44299425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44307156-44308129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44308130-44309102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44324475-44325020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44325021-44325566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44331667-44332595 Neighboring gene ALX homeobox 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44356123-44356691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44386509-44387008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4653 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:44435693-44436892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44448301-44449231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44487974-44488970 Neighboring gene uncharacterized LOC105376645

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085700.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    44197256..44198455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    44352610..44353809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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