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LOC126861196 CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:40669848-40671047 [ Homo sapiens (human) ]

Gene ID: 126861196, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861196
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:40669848-40671047
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861196 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (40648298..40649497)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (40795190..40796389)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121095-40121596 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121597-40122096 Neighboring gene zinc finger CCHC-type containing 9 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:40173418-40174617 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40224036-40224631 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40225695-40226477 Neighboring gene NANOG hESC enhancer GRCh37_chr11:40248664-40249165 Neighboring gene leucine rich repeat containing 4C Neighboring gene zinc finger protein 12 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:40700680-40701265 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40816984-40817169 Neighboring gene Sharpr-MPRA regulatory region 9582 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41138490-41139031 Neighboring gene RNA, U6 small nuclear 365, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr11:41216161-41216333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:41266457-41267413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:41324368-41325026 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41414109-41414610 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41448963-41449564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41519459-41520022 Neighboring gene ribosomal protein L9 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085695.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    40648298..40649497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    40795190..40796389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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