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LOC126861195 MED14-independent group 3 enhancer GRCh37_chr11:40173418-40174617 [ Homo sapiens (human) ]

Gene ID: 126861195, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861195
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:40173418-40174617
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (40151868..40153171)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (40298422..40299725)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376637 Neighboring gene adaptor related protein complex 5 subunit mu 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:39902599-39903100 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40005787-40006001 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40052323-40052873 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121095-40121596 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121597-40122096 Neighboring gene zinc finger CCHC-type containing 9 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40224036-40224631 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40225695-40226477 Neighboring gene NANOG hESC enhancer GRCh37_chr11:40248664-40249165 Neighboring gene leucine rich repeat containing 4C Neighboring gene zinc finger protein 12 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:40669848-40671047 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:40700680-40701265 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40816984-40817169 Neighboring gene Sharpr-MPRA regulatory region 9582 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41138490-41139031 Neighboring gene RNA, U6 small nuclear 365, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K4me1 hESC enhancer GRCh37_chr11:40174221-40174721

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085694.2 

    Range
    101..1404
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    40151868..40153171
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    40298422..40299725
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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