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LOC126861131 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:7927046-7928245 [ Homo sapiens (human) ]

Gene ID: 126861131, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861131
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:7927046-7928245
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors in HCT116 colorectal carcinoma cells, with strong dependence on P300/CBP. Two subregions were also shown to be active enhancers by ChIP-STARR-seq in naive human embryonic stem cells, where both are associated with the NANOG transcription factor and are marked by the H3K27ac histone modification, and one is additionally marked by H3K4me1. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC126861131 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7905499..7906698)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (7984645..7985844)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC283299 Neighboring gene olfactory receptor family 5 subfamily E member 1 pseudogene Neighboring gene RNA, U6 small nuclear 943, pseudogene Neighboring gene uncharacterized LOC107984307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:7929223-7929766 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:7933845-7934345 Neighboring gene olfactory receptor family 10 subfamily A member 6 (gene/pseudogene) Neighboring gene olfactory receptor family 10 subfamily A member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • NANOG-H3K27ac hESC enhancer GRCh37_chr11:7927047-7927590
  • NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:7927591-7928134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085630.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    7905499..7906698
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332695.1 Reference GRCh38.p14 PATCHES

    Range
    136493..137692
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187583.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    137000..138199
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    7984645..7985844
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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