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LOC126861072 CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:125927283-125928482 [ Homo sapiens (human) ]

Gene ID: 126861072, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126861072
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:125927283-125928482
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861072 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (124238714..124239913)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (125116649..125117854)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125927283..125928482)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125779847-125780352 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125780353-125780859 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125785865-125786861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793037-125793559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125793560-125794081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2906 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125807976-125808476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125808477-125808977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125810019-125810519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125816334-125816862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125819356-125820031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125832991-125833492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125833493-125833992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4163 Neighboring gene uncharacterized LOC105378536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4165 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:125929584-125930147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125936098-125936598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125958373-125958874 Neighboring gene uncharacterized LOC107984184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125996111-125997098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:126009557-126010056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:126067885-126068602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2908 Neighboring gene NANOG hESC enhancer GRCh37_chr10:126092029-126092572 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:126107534-126108193 Neighboring gene ornithine aminotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085571.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    124238714..124239913
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    125116649..125117854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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