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LOC126861043 CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115112200-115113399 [ Homo sapiens (human) ]

Gene ID: 126861043, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861043
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115112200-115113399
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (113352441..113353640)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (114243718..114244917)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:114812726-114813704 and GRCh37_chr10:114813705-114814683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114816611-114817110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114817902-114818530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114833929-114834698 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:114836009-114836602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114838433-114838934 Neighboring gene small nucleolar RNA, H/ACA box 87 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:114846446-114846998 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:114860474-114860640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2836 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:114894802-114895390 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:114935734-114935902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114943039-114943540 Neighboring gene NANOG hESC enhancer GRCh37_chr10:115012887-115013388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4069 Neighboring gene uncharacterized LOC105378490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:115118149-115118913 Neighboring gene RNA, U7 small nuclear 165 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:115141212-115142411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115161035-115161535 Neighboring gene Sharpr-MPRA regulatory region 9752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115213798-115214298 Neighboring gene Sharpr-MPRA regulatory region 1511 Neighboring gene uncharacterized LOC107984270 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:115251436-115252635 Neighboring gene uncharacterized LOC124902504 Neighboring gene peptidylprolyl isomerase A pseudogene 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085542.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    113352441..113353640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    114243718..114244917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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