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LOC126860972 MED14-independent group 3 enhancer GRCh37_chr10:80015479-80016678 [ Homo sapiens (human) ]

Gene ID: 126860972, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860972
Gene description
MED14-independent group 3 enhancer GRCh37_chr10:80015479-80016678
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860972 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (78255722..78256921)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (79124797..79125996)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80011981-80012494 Neighboring gene long intergenic non-protein coding RNA 856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80026770-80027320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80027321-80027869 Neighboring gene long intergenic non-protein coding RNA 595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:80052421-80053352 Neighboring gene uncharacterized LOC124902468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:80088023-80088524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085471.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    78255722..78256921
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    79124797..79125996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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