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LOC126860961 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:75691709-75692908 [ Homo sapiens (human) ]

Gene ID: 126860961, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860961
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:75691709-75692908
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes three accessible chromatin subregions, two of which were validated as silencers and one as an enhancer based on their ability to repress or activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73931951..73933150)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74803342..74804541)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75668366-75669565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:75672789-75673988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75679930-75680578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75680579-75681225 Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75716666-75717173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3586 Neighboring gene Sharpr-MPRA regulatory region 4338 Neighboring gene VISTA enhancer hs2142 Neighboring gene Sharpr-MPRA regulatory region 295 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2661 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75758175-75758826 Neighboring gene Sharpr-MPRA regulatory region 4496 Neighboring gene vinculin Neighboring gene uncharacterized LOC124902455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3588 Neighboring gene uncharacterized LOC124902458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 3583
  • ATAC-STARR-seq lymphoblastoid silent region 2496
  • ATAC-STARR-seq lymphoblastoid silent region 2497

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085460.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73931951..73933150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74803342..74804541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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