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LOC126860922 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:44796158-44797357 [ Homo sapiens (human) ]

Gene ID: 126860922, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860922
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:44796158-44797357
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860922 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44300710..44301909)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45181554..45182753)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902543 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:44607592-44608157 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12804 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12798 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:44664362-44665561 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44688953-44689454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44689455-44689954 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44703238-44703811 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44728896-44729550 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44729551-44730205 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:44730206-44730859 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_13072 Neighboring gene VISTA enhancer hs2509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3311 Neighboring gene uncharacterized LOC124902544 Neighboring gene NANOG hESC enhancer GRCh37_chr10:44793368-44793869 Neighboring gene long intergenic non-protein coding RNA 2881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3312 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:44805333-44805502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44806263-44806765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2339 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:44821405-44821620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:44833715-44834216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44852471-44853402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44859545-44860046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44860047-44860546 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:44866272-44866820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44873825-44874771 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44878101-44878794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44878795-44879488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44879489-44880180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2340 Neighboring gene uncharacterized LOC107984179 Neighboring gene C-X-C motif chemokine ligand 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44890534-44891279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44891280-44892024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:44894259-44895003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44895004-44895748 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:44895749-44896492

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085421.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    44300710..44301909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    45181554..45182753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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