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LOC126860777 BRD4-independent group 4 enhancer GRCh37_chr9:133927058-133928257 [ Homo sapiens (human) ]

Gene ID: 126860777, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860777
Gene description
BRD4-independent group 4 enhancer GRCh37_chr9:133927058-133928257
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131051671..131052870)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143259894..143261093)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene fibrinogen C domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 15615 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133818700-133818873 Neighboring gene FIBCD1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133822337-133822542 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133835976-133836150 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:133837863-133838450 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:133838451-133839037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133856871-133857391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133861291-133862162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133870475-133871031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133887620-133888188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133888189-133888756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133888757-133889324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133892018-133892589 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133894433-133894620 Neighboring gene uncharacterized LOC124900284 Neighboring gene laminin subunit gamma 3 Neighboring gene LAMC3 intron enhancer-blocking element 9-5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133925447-133925947 Neighboring gene LAMC3 intron enhancer-blocking element 9-2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133933565-133934066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133944345-133944854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133954421-133954984 Neighboring gene uncharacterized LOC124902289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133967720-133968318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133968319-133968915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133969713-133970214 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133972255-133972754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133976923-133977473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133977739-133978658 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133983561-133984060 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133985267-133985946 Neighboring gene allograft inflammatory factor 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085276.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    131051671..131052870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143259894..143261093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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