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LOC126860776 CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:133756258-133757457 [ Homo sapiens (human) ]

Gene ID: 126860776, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860776
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:133756258-133757457
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (130880871..130882070)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143085744..143086943)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ABL breakpoint recombination region Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene uncharacterized LOC124902288 Neighboring gene uncharacterized LOC124902287 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133709696-133710222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133710223-133710748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20408 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:133722835-133723457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735115-133735964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735965-133736812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133737874-133738374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133738375-133738875 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:133741863-133742364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133759146-133759916 Neighboring gene Sharpr-MPRA regulatory region 3771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133769017-133769531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133770320-133771007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133771008-133771694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133789692-133790384 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133794286-133794826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133796861-133797810 Neighboring gene fibrinogen C domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133798030-133798213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133798761-133799708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133805119-133805663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133814336-133815266 Neighboring gene FIBCD1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085275.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    130880871..130882070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143085744..143086943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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