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LOC126860766 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:129236685-129237884 [ Homo sapiens (human) ]

Gene ID: 126860766, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860766
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:129236685-129237884
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (126474406..126475605)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (138680187..138681386)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene multivesicular body subunit 12B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129177967-129178559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129183037-129183720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129183721-129184405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129185921-129186420 Neighboring gene uncharacterized LOC124902337 Neighboring gene VISTA enhancer hs186 Neighboring gene non-coding repressor of NFAT Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129214117-129214618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129238046-129238625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129238626-129239204 Neighboring gene Sharpr-MPRA regulatory region 3753 Neighboring gene Sharpr-MPRA regulatory region 6068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129270146-129270646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20288 Neighboring gene uncharacterized LOC105376276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129281950-129282456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129283760-129284260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129284261-129284761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129293424-129294057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129296024-129296550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129296551-129297075 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129297602-129298126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129298952-129299452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129299453-129299953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129319165-129319741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129345084-129345584 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129350068-129350902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129350903-129351737 Neighboring gene uncharacterized LOC124902272

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085265.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    126474406..126475605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    138680187..138681386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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