U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126860762 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127071689-127072888 [ Homo sapiens (human) ]

Gene ID: 126860762, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126860762
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127071689-127072888
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126860762 in Genome Data Viewer
Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124309410..124311023)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136507497..136509110)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127020845-127021790 Neighboring gene uncharacterized LOC124902268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127026232-127026845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20262 Neighboring gene uncharacterized LOC613206 Neighboring gene NIMA related kinase 6 Neighboring gene Sharpr-MPRA regulatory region 10556 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127047786-127047960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:127048049-127049248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127054700-127055684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127058683-127059590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127061405-127062310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127070759-127071606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127077520-127078020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127104704-127105575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127105576-127106448 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106555 Neighboring gene uncharacterized LOC100129034 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC124902267

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

General gene information

Go to the top of the page Help

Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127072455-127073302

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085261.2 

    Range
    101..1714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124309410..124311023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    136507497..136509110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases