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LOC126860754 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:124801206-124802405 [ Homo sapiens (human) ]

Gene ID: 126860754, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860754
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:124801206-124802405
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860754 in Genome Data Viewer
Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122038927..122040126)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134236392..134237591)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DAB2 interacting protein Neighboring gene uncharacterized LOC105376257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124500148-124500924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124504941-124505640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124510791-124511314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:124514713-124515213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124516632-124517247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124517370-124517953 Neighboring gene Sharpr-MPRA regulatory region 3775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124543874-124544863 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:124552172-124552712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:124556939-124557676 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:124558413-124559150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124573577-124574096 Neighboring gene uncharacterized LOC107987125 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124578825-124579621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124589529-124590300 Neighboring gene tubulin tyrosine ligase like 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124650231-124650789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124659227-124659916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124688418-124688918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124748015-124748516 Neighboring gene uncharacterized LOC124902262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124855115-124855828 Neighboring gene uncharacterized LOC124902263

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085254.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    122038927..122040126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    134236392..134237591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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