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LOC126860547 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:142745139-142746338 [ Homo sapiens (human) ]

Gene ID: 126860547, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860547
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:142745139-142746338
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860547 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141734937..141736136)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142865992..142867191)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142745139..142746338)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142545064-142545649 Neighboring gene chromosome 8 open reading frame 90 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142558100-142558604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142558605-142559109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142561559-142562060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142562061-142562560 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142566739-142567001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142569505-142570496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142570497-142571488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142585360-142585860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142587423-142588412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142591081-142591580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142592469-142593282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142599778-142600296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142608084-142608974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142623529-142624078 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142653536-142653719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142655873-142656419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142659443-142660272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142689993-142690836 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142692286-142692461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142710650-142711224 Neighboring gene MPRA-validated peak7195 silencer Neighboring gene uncharacterized LOC124902074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142740701-142741201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142867983-142868600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142868601-142869216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142870449-142871065 Neighboring gene microRNA 1302-7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142934035-142934535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142955329-142955830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142990054-142990633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142990634-142991212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143011659-143012630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143012631-143013602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143014855-143015446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28055 Neighboring gene DNAJC8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085047.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141734937..141736136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142865992..142867191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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