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LOC126860544 MED14-independent group 3 enhancer GRCh37_chr8:141567119-141568318 [ Homo sapiens (human) ]

Gene ID: 126860544, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860544
Gene description
MED14-independent group 3 enhancer GRCh37_chr8:141567119-141568318
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860544 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140557020..140558219)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141677381..141678580)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141567119..141568318)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:141474198-141475397 Neighboring gene uncharacterized LOC105375782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19579 Neighboring gene MPRA-validated peak7190 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141518766-141518946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28029 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141537549-141538050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141538051-141538550 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141554768-141555545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141559982-141560482 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:141569579-141570778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141578119-141578876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141603574-141604074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141607590-141608092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141619067-141620038 Neighboring gene MAGE-like protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141634221-141635220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141635221-141636221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141640637-141641137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643203-141643970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643971-141644737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19583 Neighboring gene E2F1-regulated inhibitor of cell death

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085044.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    140557020..140558219
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    141677381..141678580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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