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LOC126860512 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:129799489-129800688 [ Homo sapiens (human) ]

Gene ID: 126860512, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860512
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:129799489-129800688
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860512 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (128787243..128788442)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (129912122..129913321)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27960 Neighboring gene RN7SK pseudogene 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27961 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:129325755-129326438 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:129327123-129327805 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:129356185-129356773 Neighboring gene NANOG hESC enhancer GRCh37_chr8:129374035-129374655 Neighboring gene long intergenic non-protein coding RNA 824 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:129566785-129567984 Neighboring gene NFE2L2 motif-containing MPRA enhancer 33 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:129624320-129625140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:129757123-129757729 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:129780448-129781388 Neighboring gene uncharacterized LOC124902021 Neighboring gene NANOG hESC enhancer GRCh37_chr8:129873252-129873850 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:129908740-129909939 Neighboring gene MPRA-validated peak7171 silencer Neighboring gene long intergenic non-protein coding RNA 976

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085012.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    128787243..128788442
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187567.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    235918..237117
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    129912122..129913321
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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