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LOC126860511 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:129179416-129180615 [ Homo sapiens (human) ]

Gene ID: 126860511, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860511
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:129179416-129180615
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860511 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (128167170..128168369)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (129294833..129296031)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (129179416..129180615)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Pvt1 oncogene Neighboring gene CRISPRi-validated MYC e4 enhancer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:129074055-129074702 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:129077402-129078601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27959 Neighboring gene microRNA 1207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:129118718-129119218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:129121159-129122087 Neighboring gene uncharacterized LOC124902020 Neighboring gene Sharpr-MPRA regulatory region 6197 Neighboring gene microRNA 1208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27960 Neighboring gene RN7SK pseudogene 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27961 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:129325755-129326438 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:129327123-129327805 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:129356185-129356773 Neighboring gene NANOG hESC enhancer GRCh37_chr8:129374035-129374655 Neighboring gene long intergenic non-protein coding RNA 824 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:129566785-129567984 Neighboring gene NFE2L2 motif-containing MPRA enhancer 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085011.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    128167170..128168369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    129294833..129296031
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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