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LOC126860500 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:126525111-126526310 [ Homo sapiens (human) ]

Gene ID: 126860500, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860500
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:126525111-126526310
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (125512869..125514068)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (126646397..126647596)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene Sharpr-MPRA regulatory region 6874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27909 Neighboring gene RNA, 7SL, cytoplasmic 329, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:126312861-126313361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27910 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126346157-126346974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:126389339-126389905 Neighboring gene Sharpr-MPRA regulatory region 8491 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126398994-126399684 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:126401291-126401791 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:126400790-126401290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126416953-126417640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126417641-126418327 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126427297-126428194 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:126428195-126429092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27913 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:126433597-126434098 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:126434099-126434598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27915 Neighboring gene Sharpr-MPRA regulatory region 8664 Neighboring gene MPRA-validated peak7163 silencer Neighboring gene tribbles pseudokinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:126513538-126514038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27917 Neighboring gene TRIB1 associated lncRNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:126533553-126534054 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:126544853-126545039 Neighboring gene long intergenic non-protein coding RNA 2964 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:126558198-126558636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:126569037-126569774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27927 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:126667345-126668544 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:126691873-126693072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27928 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:126745383-126745936 Neighboring gene uncharacterized LOC105375747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 27918

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085000.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    125512869..125514068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    126646397..126647596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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