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LOC126860390 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:54640179-54641378 [ Homo sapiens (human) ]

Gene ID: 126860390, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860390
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:54640179-54641378
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (53727619..53728818)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (54105035..54106234)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr8:54461749-54462250 Neighboring gene mitogen-activated protein kinase 6 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54522094-54522758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54554567-54555068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54570356-54571160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54571161-54571965 Neighboring gene NANOG hESC enhancer GRCh37_chr8:54572274-54572814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54605084-54605594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54605595-54606103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54612999-54613500 Neighboring gene chromosome 5 open reading frame 13 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27359 Neighboring gene ATPase H+ transporting V1 subunit H Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54789287-54789787 Neighboring gene Sharpr-MPRA regulatory region 5984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54793331-54793962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:54793963-54794594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27363 Neighboring gene regulator of G protein signaling 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27366 Neighboring gene RPS27A pseudogene 13 Neighboring gene RNA, U6 small nuclear 1331, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084890.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    53727619..53728818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    54105035..54106234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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