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LOC126860370 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41592277-41593476 [ Homo sapiens (human) ]

Gene ID: 126860370, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860370
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41592277-41593476
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860370 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41734759..41735958)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (42008337..42009536)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41510853-41511646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41513473-41514006 Neighboring gene NK6 homeobox 3 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene ankyrin 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41541049-41542248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41543347-41543848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41543849-41544348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27293 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41570734-41571933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41574438-41575290 Neighboring gene Sharpr-MPRA regulatory region 1462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41591757-41592299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41593686-41594662 Neighboring gene Sharpr-MPRA regulatory region 338 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:41649575-41650774 Neighboring gene uncharacterized LOC105379392 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41656213-41657412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41666802-41667754 Neighboring gene Sharpr-MPRA regulatory region 6451 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:41675890-41677089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41685500-41686057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41691339-41692069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41692070-41692799 Neighboring gene RNA, 7SL, cytoplasmic 149, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084870.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    41734759..41735958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    42008337..42009536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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