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LOC126860305 MED14-independent group 3 enhancer GRCh37_chr8:12947375-12948574 [ Homo sapiens (human) ]

Gene ID: 126860305, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860305
Gene description
MED14-independent group 3 enhancer GRCh37_chr8:12947375-12948574
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860305 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (13089866..13091065)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (13356335..13357534)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12947375..12948574)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12915937-12916437 Neighboring gene RNA, U6 small nuclear 842, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:12957644-12958023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12962666-12963312 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12965381-12965880 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980176-12980808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12980809-12981441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982170-12982670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12982671-12983171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18957 Neighboring gene DLC1 Rho GTPase activating protein Neighboring gene uncharacterized LOC101930149 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:13223844-13225043 Neighboring gene MT-ND4 pseudogene 7 Neighboring gene uncharacterized LOC124901890

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084805.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    13089866..13091065
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    6285456..6286656
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    13356335..13357534
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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