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LOC126860299 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:9046079-9047278 [ Homo sapiens (human) ]

Gene ID: 126860299, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860299
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:9046079-9047278
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC126860299 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (9187937..9189768)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (10554272..10556103, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901882 Neighboring gene protein phosphatase 1 regulatory subunit 3B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:9007568-9008516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18906 Neighboring gene PPP1R3B divergent transcript Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:9040517-9041502 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:9041503-9042488 Neighboring gene uncharacterized LOC101929128 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:9106826-9107326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:9114015-9114515 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:9120655-9121382 Neighboring gene Sharpr-MPRA regulatory region 719 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:9127271-9127799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:9134231-9134732 Neighboring gene RNA, U6 small nuclear 1151, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac hESC enhancer GRCh37_chr8:9045447-9046432

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084799.2 

    Range
    101..1932
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    9187937..9189768
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    4161804..4163635 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    10554272..10556103 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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