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LOC126860283 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:2362643-2363842 [ Homo sapiens (human) ]

Gene ID: 126860283, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860283
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:2362643-2363842
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (2505530..2506729)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (2259060..2260259)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:2198229-2199013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:2199014-2199799 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:2204711-2204884 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:2206168-2207367 duplicate 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:2212147-2212701 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:2224809-2224986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:2230117-2230734 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:2231642-2232172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:2244841-2245340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:2282596-2283334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:2283335-2284073 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:2206168-2207367 duplicate 2 Neighboring gene uncharacterized LOC105377784 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:2382994-2383722 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:2383723-2384449 Neighboring gene long intergenic non-protein coding RNA 3021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:2419495-2420034 Neighboring gene uncharacterized LOC107986865 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:2547000-2547500 Neighboring gene uncharacterized LOC105377785 Neighboring gene Sharpr-MPRA regulatory region 12422 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:2670718-2671218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:2671219-2671719 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:2734767-2735966 Neighboring gene Sharpr-MPRA regulatory region 746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:2743811-2744593 Neighboring gene uncharacterized LOC124901871 Neighboring gene Sharpr-MPRA regulatory region 9194

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084784.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    2505530..2506729
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187576.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    673213..674412
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    2259060..2260259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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