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LOC126860277 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:1703542-1704741 [ Homo sapiens (human) ]

Gene ID: 126860277, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860277
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:1703542-1704741
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (1755376..1756575)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (1534044..1535243)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DLG associated protein 2 Neighboring gene uncharacterized LOC124901870 Neighboring gene conserved acetylation island sequence 7 enhancer Neighboring gene DNA fragmentation factor subunit alpha pseudogene Neighboring gene uncharacterized LOC105377778 Neighboring gene Sharpr-MPRA regulatory region 8503 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1719100-1719280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1726288-1727208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1731879-1732378 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1733452-1733574 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1748222-1749421 Neighboring gene CLN8 antisense RNA 1 Neighboring gene microRNA 3674 Neighboring gene CLN8 transmembrane ER and ERGIC protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084778.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    1755376..1756575
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187680.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    168034..169233
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    1534044..1535243
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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