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LOC126860275 CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1552920-1554119 [ Homo sapiens (human) ]

Gene ID: 126860275, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860275
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1552920-1554119
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (1604754..1605953)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (1383843..1385042)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DLG associated protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1321423-1321923 Neighboring gene keratinocyte proline-rich protein-like Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:1322036-1322849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1325138-1326080 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1365595-1365747 Neighboring gene uncharacterized LOC105377775 Neighboring gene uncharacterized LOC105379586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1385309-1385823 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1403885-1405084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1427697-1428250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1449675-1450203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1455237-1455738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1455739-1456238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1487477-1487978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1487979-1488478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1525979-1526505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1534609-1535108 Neighboring gene DLGAP2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1555917-1556470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1574652-1575623 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:1580608-1581807 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1585200-1585433 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:1605998-1606719 Neighboring gene uncharacterized LOC124901870 Neighboring gene conserved acetylation island sequence 7 enhancer Neighboring gene DNA fragmentation factor subunit alpha pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084776.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    1604754..1605953
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187654.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    214484..215683
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187680.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    17950..19149
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    1383843..1385042
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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