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LOC126860249 BRD4-independent group 4 enhancer GRCh37_chr7:155855824-155857023 [ Homo sapiens (human) ]

Gene ID: 126860249, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860249
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:155855824-155857023
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860249 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (156063130..156064329)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (157250115..157251314)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (155855824..155857023)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:155754590-155755789 Neighboring gene uncharacterized LOC389602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155766793-155767294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155767295-155767794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155790505-155791005 Neighboring gene uncharacterized LOC105375597 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:155815211-155815389 Neighboring gene uncharacterized LOC124901789 Neighboring gene MPRA-validated peak6866 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26906 Neighboring gene SHH silencer LOC106049962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:155857309-155858508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:155884497-155884996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155898353-155899150 Neighboring gene uncharacterized LOC105375603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:155936145-155936722 Neighboring gene uncharacterized LOC105375602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084750.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    156063130..156064329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    157250115..157251314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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