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LOC126860095 CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:86176787-86177986 [ Homo sapiens (human) ]

Gene ID: 126860095, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126860095
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:86176787-86177986
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (86547471..86548670)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (87797423..87798622)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85053215-85054073 Neighboring gene long intergenic non-protein coding RNA 972 Neighboring gene NANOG hESC enhancer GRCh37_chr7:85260046-85260587 Neighboring gene NANOG hESC enhancer GRCh37_chr7:85315988-85316510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26220 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:85557785-85558332 Neighboring gene suppressor of cytokine signaling 5 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:85958016-85958801 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85969252-85969876 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:85969877-85970501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:86337538-86338062 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:86389511-86390085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26223 Neighboring gene glutamate metabotropic receptor 3 Neighboring gene GRM3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578298-86578835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578836-86579372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18340 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene MPRA-validated peak6623 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:86687932-86688432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18342

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084596.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    86547471..86548670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    87797423..87798622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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