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LOC126860087 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:81487648-81488847 [ Homo sapiens (human) ]

Gene ID: 126860087, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126860087
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:81487648-81488847
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126860087 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (81858332..81859531)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (83109445..83110644)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81487648..81488847)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128317 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:81252185-81253384 Neighboring gene DEAD-box helicase 43 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:81302077-81302610 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18335 Neighboring gene hepatocyte growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26212 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene CACNA2D1 antisense RNA 1 Neighboring gene uncharacterized LOC124901687

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084588.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    81858332..81859531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    83109445..83110644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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