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LOC126859940 CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:8254569-8255768 [ Homo sapiens (human) ]

Gene ID: 126859940, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859940
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:8254569-8255768
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859940 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (8214939..8216138)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (8333538..8334737)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 4 pseudogene Neighboring gene glucocorticoid induced 1 Neighboring gene MPRA-validated peak6363 silencer Neighboring gene uncharacterized LOC105375142 Neighboring gene NANOG hESC enhancer GRCh37_chr7:8144287-8144833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:8164462-8165254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25657 Neighboring gene NANOG hESC enhancer GRCh37_chr7:8186642-8187159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25658 Neighboring gene islet cell autoantigen 1 Neighboring gene uncharacterized LOC124901587 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:8261122-8261678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8342998-8343560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8343561-8344122 Neighboring gene ICA1 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8391097-8391728 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8391729-8392358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8473803-8474350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8474351-8474898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8474899-8475446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8480847-8481347 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:8482526-8482705 Neighboring gene neurexophilin 1 Neighboring gene uncharacterized LOC105375144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084441.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    8214939..8216138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    8333538..8334737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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