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LOC126859925 MED14-independent group 3 enhancer GRCh37_chr7:2019399-2020598 [ Homo sapiens (human) ]

Gene ID: 126859925, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859925
Gene description
MED14-independent group 3 enhancer GRCh37_chr7:2019399-2020598
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells, where it was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. A subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC126859925 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1979764..1980963)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (2094438..2095637)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene extracellular leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25499 Neighboring gene ELFN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1847611-1848112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1848113-1848612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1852667-1853242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1878277-1879182 Neighboring gene uncharacterized LOC100127955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1887449-1888158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1896343-1897150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1897151-1897958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1897959-1898765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1900385-1901202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1901203-1902019 Neighboring gene mitotic arrest deficient 1 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1902954-1903628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1913269-1914241 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98143 Neighboring gene microRNA 4655 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1923010-1923799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1930010-1930510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1930511-1931011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1940274-1941134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1952585-1953218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1951951-1952584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1951273-1951773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1970348-1971296 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1979601-1980186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1985471-1986286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1986287-1987101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1994453-1995177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1997460-1998140 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:2000936-2002135 Neighboring gene uncharacterized LOC124901573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2037703-2038424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2041223-2042211 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:2054673-2054929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2059628-2060447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2071047-2071728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2072411-2073090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2089101-2089704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2094763-2095278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2095767-2096320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2096321-2096873 Neighboring gene Sharpr-MPRA regulatory region 15277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2109248-2109803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2109804-2110358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2112531-2113084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2113104-2113604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2117862-2118431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2118432-2119000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2119001-2119570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2119571-2120138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2143023-2143689 Neighboring gene Sharpr-MPRA regulatory region 12408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2145023-2145690 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:2149574-2150773 Neighboring gene uncharacterized LOC105375127 Neighboring gene small nucleolar RNA, H/ACA box 114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2019793-2020444

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084426.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1979764..1980963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    2094438..2095637
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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