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LOC126859900 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:168568969-168570168 [ Homo sapiens (human) ]

Gene ID: 126859900, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859900
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:168568969-168570168
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859900 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (168168289..168169488)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (169509643..169510813)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168459591-168460092 Neighboring gene FERM domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168478883-168479604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168482533-168483533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168483534-168484533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168499911-168500412 Neighboring gene uncharacterized LOC107986548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168506640-168507627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168518029-168518528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168521725-168522286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168525719-168526232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168529825-168530422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168551001-168551637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168556329-168557328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168557329-168558326 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168558327-168559325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168580313-168581020 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:168590405-168591604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168594074-168594641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168594898-168595547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168595548-168596196 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:168608743-168609449 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:168609450-168610156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168615624-168616124 Neighboring gene uncharacterized LOC105378137 Neighboring gene uncharacterized LOC124901501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:168631271-168631772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084401.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    168168289..168169488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    169509643..169510813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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