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LOC126859891 BRD4-independent group 4 enhancer GRCh37_chr6:166917274-166918473 [ Homo sapiens (human) ]

Gene ID: 126859891, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859891
Gene description
BRD4-independent group 4 enhancer GRCh37_chr6:166917274-166918473
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (166503786..166504985)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (167881299..167882498)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166848811-166849312 Neighboring gene ribosomal protein S6 kinase A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:166863042-166863708 Neighboring gene RPS6KA2 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883011-166883914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883915-166884818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166889542-166890188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166899351-166899851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166903150-166903650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166908262-166908949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166920565-166921504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166919624-166920564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166946507-166947008 Neighboring gene microRNA 1913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25436 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:166955818-166956418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166956766-166957686 Neighboring gene NANOG hESC enhancer GRCh37_chr6:166965189-166965763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166978541-166979078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:166985773-166986662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993250-166993750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993751-166994251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166994332-166995152 Neighboring gene RNA guanine-7 methyltransferase activating subunit like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084392.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    166503786..166504985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    167881299..167882498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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