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LOC126859880 CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:164664227-164665426 [ Homo sapiens (human) ]

Gene ID: 126859880, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126859880
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:164664227-164665426
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859880 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (164243195..164244394)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (165607987..165609186)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (164664227..164665426)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378102 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:164361763-164362454 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:164364039-164364692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:164365590-164366091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:164366092-164366592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:164372861-164373361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:164381233-164382004 Neighboring gene VISTA enhancer hs1955 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:164489884-164491083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:164500883-164501384 Neighboring gene uncharacterized LOC105378106 Neighboring gene Sharpr-MPRA regulatory region 12678 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:164648817-164650016 Neighboring gene uncharacterized LOC105378109 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:164757982-164759181 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:164764686-164765488 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:164765489-164766289 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:164800638-164801837 Neighboring gene uncharacterized LOC105379712

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084381.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    164243195..164244394
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    165607987..165609186
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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