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LOC126859851 MED14-independent group 3 enhancer GRCh37_chr6:159193631-159194830 [ Homo sapiens (human) ]

Gene ID: 126859851, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859851
Gene description
MED14-independent group 3 enhancer GRCh37_chr6:159193631-159194830
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (158772599..158773798)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (160017831..160019030)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin like 3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:159151193-159152392 Neighboring gene AMZ2 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159176343-159176927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159180075-159180750 Neighboring gene Sharpr-MPRA regulatory region 4567 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159192487-159192693 Neighboring gene microRNA 3918 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:159205226-159206425 Neighboring gene ezrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159245802-159246776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25370 Neighboring gene EZR antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159256297-159256987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159256988-159257678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159273679-159274204 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159274205-159274730 Neighboring gene uncharacterized LOC124901448 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159274731-159275254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25373 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159275781-159276305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159276306-159276830 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084352.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    158772599..158773798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    160017831..160019030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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