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LOC126859784 CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:129822854-129824053 [ Homo sapiens (human) ]

Gene ID: 126859784, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859784
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:129822854-129824053
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859784 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (129501709..129502908)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (130695377..130696576)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chr6:129761748-129762353 Neighboring gene RNA, U6 small nuclear 861, pseudogene Neighboring gene uncharacterized LOC124901401 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:129811717-129812916 Neighboring gene uncharacterized LOC102723409 Neighboring gene Sharpr-MPRA regulatory region 13537 Neighboring gene MPRA-validated peak6120 silencer Neighboring gene Rho GTPase activating protein 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17533 Neighboring gene Sharpr-MPRA regulatory region 14599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25049 Neighboring gene ribosomal protein L5 pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084285.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    129501709..129502908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    130695377..130696576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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