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LOC126859593 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:13466168-13467367 [ Homo sapiens (human) ]

Gene ID: 126859593, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126859593
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:13466168-13467367
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859593 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13465936..13467135)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13339455..13340654)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13466168..13467367)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901261 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13328608-13329114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16927 Neighboring gene uncharacterized LOC105374936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16928 Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16929 Neighboring gene MPRA-validated peak5665 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24025 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:13422205-13422994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13461923-13462595 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:13462671-13463323 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:13463324-13463975 Neighboring gene Sharpr-MPRA regulatory region 12646 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:13479720-13480919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24032 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:13487020-13487183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24034 Neighboring gene GFOD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24035 Neighboring gene ribosomal protein S4X pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084094.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    13465936..13467135
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    13339455..13340654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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