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LOC126807629 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:179868388-179869587 [ Homo sapiens (human) ]

Gene ID: 126807629, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807629
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:179868388-179869587
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180441388..180442587)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (180996901..180998099)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16763 Neighboring gene uncharacterized LOC124901151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179719561-179720203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179726045-179726545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179732911-179733425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179733426-179733939 Neighboring gene Sharpr-MPRA regulatory region 4162 Neighboring gene glutamine-fructose-6-phosphate transaminase 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:179750129-179750814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179755849-179756838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179756839-179757826 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:179758817-179759804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179760793-179761780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179763140-179763684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179763685-179764228 Neighboring gene Sharpr-MPRA regulatory region 8548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179770451-179771368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179778490-179778990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179797271-179797772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179850841-179851340 Neighboring gene uncharacterized LOC124901152 Neighboring gene RNA, U6 small nuclear 525, pseudogene Neighboring gene uncharacterized LOC124901153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083943.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180441388..180442587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    180996901..180998099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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