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LOC126807617 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806 [ Homo sapiens (human) ]

Gene ID: 126807617, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807617
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176787606..176788805)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177334204..177335403)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480 Neighboring gene uncharacterized LOC124901144 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176093385-176093611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176098601-176099166 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176099167-176099730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176106874-176107834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176107835-176108794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176119741-176120285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176124309-176125132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176126779-176127601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176139283-176140243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176148139-176148638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152218-176152749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152750-176153280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176159360-176160290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176160291-176161220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176167545-176168254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176170772-176171740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176174798-176175456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176176117-176176775 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176211747-176212340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176212935-176213528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176219277-176220119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176220120-176220961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176225159-176226105 Neighboring gene MPRA-validated peak5589 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176257203-176258159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176271727-176272558 Neighboring gene unc-5 netrin receptor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176284513-176285014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176295664-176296411 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176299555-176299736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176302473-176303396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176306956-176307321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176314417-176314917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176327167-176327668 Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176370315-176371173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176371174-176372031 Neighboring gene uncharacterized LOC124901145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083931.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176787606..176788805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177334204..177335403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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