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LOC126807593 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:169757700-169758899 [ Homo sapiens (human) ]

Gene ID: 126807593, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807593
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:169757700-169758899
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126807593 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170330696..170331895)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (170869544..170870739)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 58 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23605 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:169730050-169731249 Neighboring gene uncharacterized LOC100128059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23607 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169759699-169760548 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169760549-169761396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23610 Neighboring gene long intergenic non-protein coding RNA 1366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169788107-169788607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169814486-169814986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169814987-169815487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169817412-169817912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169817913-169818413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169818666-169819166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169819167-169819667 Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene KCNIP1 overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16606 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 23608

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083907.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    170330696..170331895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    170869544..170870739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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