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LOC126807561 BRD4-independent group 4 enhancer GRCh37_chr5:152731661-152732860 [ Homo sapiens (human) ]

Gene ID: 126807561, updated on 10-Oct-2023

Summary

Gene symbol
LOC126807561
Gene description
BRD4-independent group 4 enhancer GRCh37_chr5:152731661-152732860
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (153352101..153353300)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (153885233..153886432)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:152022318-152022903 Neighboring gene tRNA-Cys (anticodon ACA) 1-1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152038685-152039224 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83142 Neighboring gene uncharacterized LOC124901117 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152147932-152148511 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:152191225-152192424 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83374 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83428 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83450 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:152415832-152416029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:152455744-152456284 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83469 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:152685418-152686617 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:152729354-152730121 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:152730122-152730888 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:152829283-152830143 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:152835859-152836432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16531 Neighboring gene glutamate ionotropic receptor AMPA type subunit 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:153162167-153162715 Neighboring gene NANOG hESC enhancer GRCh37_chr5:153170808-153171397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16532 Neighboring gene RNA, 7SL, cytoplasmic 177, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:153204359-153204899 Neighboring gene long intergenic non-protein coding RNA 1861

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083875.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    153352101..153353300
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    153885233..153886432
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    GenBank, FASTA, Sequence Viewer (Graphics)