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LOC126807535 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142388320-142389519 [ Homo sapiens (human) ]

Gene ID: 126807535, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126807535
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142388320-142389519
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807535 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (143008755..143009954)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143540054..143541253)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142275426-142276332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296188-142296688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296689-142297189 Neighboring gene uncharacterized LOC107986457 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142361413-142362255 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142362256-142363097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23324 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142416478-142417238 Neighboring gene uncharacterized LOC124901097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:142469655-142470246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142472885-142473646 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142473647-142474407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23327 Neighboring gene uncharacterized LOC124901098

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083849.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    143008755..143009954
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    143540054..143541253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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